Scaled down models are becoming increasingly important to cell line and media development, as well as overall process optimization. These models provide the opportunity to run multiple experiments in parallel at a fraction of the time and cost it would take to run larger scale experiments. In many cases, without scale down models, incredibly informative multi-factorial experiments would not be feasible.
Scaled down, high-cell density N-1 and continuous perfusion cultures are important to data quality, increased staff productivity, and shorter development timelines for bioprocess development. Currently, high-throughput scale-down models are only able to approximate perfusion culture (and at low VCD) with daily media exchanges and only limited sensing and control options. Bench scale stirred tank bioreactors are predominantly used, but they take time to setup and operate. They also require significant amounts of media and other consumables, which can be costly.
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