As companies are expanding into development of new biotech products there are mounting pressures to be faster and managing costs becomes a challenge. Erbi Breez has been developed to allow customers the ability to culture cells without limitations. The Breez can serve as a scale-up or scale-down model for process intensification and continuous processes that require True PerfusionTM while providing high gas transfer, O2 delivery, and CO2 stripping with low mechanical stress. Having a closed loop control over pH, DO, temperature, and cell density all at a 2 mL scale enables the Erbi Breez to provide a great model for optimization of all scale independent process parameters.
Speed: Save time with a pre-sterilized microbioreactor cassette and integrated fluid delivery system with automated setup & calibration. No assembly, sterilization, or tear down time.
Individualized automation: Breez bioreactors can operate independently or in parallel. They have an integrated filter to autonomously manage perfusion flow, enabling hands free flow control for applications such as N-1 Perfusion, media exchange, or cell concentration.
High performance: Reach cell densities in perfusion culture (>200M CHO cells/ml).
Scale-down model: Understand your large-scale processes with 1000-fold reduction in media and reagent costs.
Hands Free Reliability: Maintains steady state perfusion for over 30 days with automated and integrated cell density, pH, DO, and temperature control.
Demonstrated Performance with CHO
Example 1: Scale-Down
- 20 experiments in 3 months
- Met customer expectations for cell density and protein titer
- Generated data comparable to equivalent 10L glass bioreactor experiments
- Enabled customer to test cell responses to mixing and different media formulations
- Significantly less touch time than running equivalent stirred tank reactors